african trypanosomiasis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27135	DDD85646	DDD 85646,DDD-85646	Parasite
	DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.		Parasite
T77645	JC-229		TRP/TRPV Channel
	JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).		TRP/TRPV Channel
T67919	NMT-IN-1		Others
	NMT-IN-1 is a potent inhibitor of N-nutyltransferase (NMT), with IC50 of 31μM for TbNMT and 66μM for hNMT. NMT-IN-1 is a potential compound for the treatment of African trypanosomiasis.		Others
T33278	Melarsoprol	Melarsoprolum,RP 3854,RP3854,RP-3854
	Melarsoprol, an organoarsenic compound, can be used to treat trypanosomiasis (human African sleeping sickness).
T34663	S-MGB-234 TFA	SMGB-234,SMGB 234,S-MGB-234,S-MGB234,SMGB234,S-MGB 234
	S-MGB-234 is a novel Minor Groove Binder that cures animal African trypanosomiasis in an in vivo mouse model. S-MGB-234 has significant potential as novel therapeutic agents for animal African trypanosomiasis.
T24587	Pafuramidine maleate	DB-289,DB289,DB 289
	Pafuramidine is an orally bioavailable prodrug of formamidine which was developed for the treatment of human African trypanosomiasis.
TN5588	Kolavenol
	Kolavenol shows a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
T40789	Eflornithine hydrochloride	MDL71782hydrochloride,RMI71782hydrochloride,DFMO hydrochloride,α-difluoromethylornithinehydrochloride
	Eflornithine hydrochloride, a specific and irreversible inhibitor of ornithine decarboxylase enzyme, is a medication used for the treatment of African trypanosomiasis and excessive facial hair growth in women.
T40811	Eflornithine	RMI71782,α-difluoromethylornithine,DFMO,MDL71782
	Eflornithine is an irreversible inhibitor that specifically targets the enzyme ornithine decarboxylase. It serves as a therapeutic medication for two conditions: the treatment of African trypanosomiasis and the managemen...
T72267	Antitrypanosomal agent 9
	Antitrypanosomal agent 9 is a potent compound with inhibitory activity against T. b. brucei, exhibiting an IC50 of 1.15 μM. It is utilized in research for human African trypanosomiasis (HAT).
T79254	Antitrypanosomal agent 14		Parasite
	Antitrypanosomal agent 14 (Compound 1), a potent T. brucei inhibitor with an effective concentration (EC50) of 0.47 μM, also inhibits Tb GSK3 with an inhibitory concentration (IC50) of 12 μM, and is utilized in the resea...		Parasite
T79253	HAT-IN-8		Parasite
	HAT-IN-8 (Compound 38), a blood-brain barrier-permeable inhibitor of Trypanosoma brucei with an EC50 of 0.18 μM, is utilized in the study of Human African trypanosomiasis [1].		Parasite
T39397	S-MGB-234
	S-MGB-234 is a minor groove binder utilized for the treatment of Animal African Trypanosomiasis (AAT). It exhibits exceptional in vitro efficacy against the primary causative agents of AAT, namely Trypanosoma congolense ...
T62362	GNF6702
	GNF6702 is a selective inhibitor of the kinetoplastid proteasome and has been shown to be effective against parasites in mouse models of leishmaniasis, Chagas disease and human African trypanosomiasis.
T14115	Acoziborole	SCYX-7158,AN5568	Others
	Acoziborole (SCYX-7158), a derivative of benzoxaborole, is a safe, effective and structurally novel antigen-worm agent for human African trypanosomiasis (HAT) studies. The MIC value of Acoziborole for T. b. brucei S427 w...		Others
T62255	20S Proteasome-IN-4
	20S Proteasome-IN-4 (Compound 7) is an orally active inhibitor of the 20S proteasome, selectively targeting the parasite form and demonstrating brain penetration capabilities. It exhibits a potent IC50 value of 6.3 nM ag...
T79568	NPD-2975		Parasite
	NPD-2975 (compound 30) is an orally active antitrypanosomal agent effective against Human African Trypanosomiasis (HAT), demonstrating acceptable metabolic stability and low toxicity potential in human MRC-5 lung fibrobl...		Parasite